VapidLapid
Ideal_Rock
- Joined
- Feb 18, 2010
- Messages
- 4,272
This Wednesday, SO is having surgery for ONJ. She has many sites in her mouth with the jaw bone exposed and no flesh to cover it. Parts of the bone are dead, and so are host to bacterial infection. That kills more bone, and leaves her swollen (sometimes dramatically), in pain and with pus drainage. She will lose 4 molars. The surgeon is hopeful that he will not have to remove a complete section of bone that would requite a metal plate be screwed in to bridge the jaw. He says he will likely only be taking off levels and layers, thinning the bone but leaving it intact. The procedures are being done at NYU Langone. After she is all healed they will make her a denture to replace the lost teeth.
The condition was caused by Xgeva, a drug she has been given monthly, nearly three years now. It is used to rebuild bone by blocking the resorptive turnover that is a natural process of the body taking itself apart and replacing older cells with newer. It is given in lower doses as a preventative for osteoporosis. In higher doses, like hers, it is used to rebuild bones that have been damaged by the metastasized breast cancer; in her case all of her vertebrae and some ribs. As she in currently in a study of fulvestrant with everolimus, the surgeon has asked the trial sponsor to give her a holiday from the everolimus, which is an mTOR inhibitor, and so interferes with cellular generation, which would also inhibit healing.
I know there has been a lot of dust going around lately for lots of worthy PSers, but If there is any still out there we could sure use a little.
PSA: Don't ever put off taking care of your health!
The condition was caused by Xgeva, a drug she has been given monthly, nearly three years now. It is used to rebuild bone by blocking the resorptive turnover that is a natural process of the body taking itself apart and replacing older cells with newer. It is given in lower doses as a preventative for osteoporosis. In higher doses, like hers, it is used to rebuild bones that have been damaged by the metastasized breast cancer; in her case all of her vertebrae and some ribs. As she in currently in a study of fulvestrant with everolimus, the surgeon has asked the trial sponsor to give her a holiday from the everolimus, which is an mTOR inhibitor, and so interferes with cellular generation, which would also inhibit healing.
I know there has been a lot of dust going around lately for lots of worthy PSers, but If there is any still out there we could sure use a little.
PSA: Don't ever put off taking care of your health!