Look at them with a loupe. Almost all synthetic opals have a honeycomb or lizard skin like pattern to them. Glass fakes have to be contained and bezel set with closed back to make them look like anything close to opal. Small white opals like those shown are not very expensive, so there's little reason to use fakes or simulants. I'd hate to say they're real from a picture, but they sure do look like it.
I would agree with Michael that I normally hesitate to say whether something is (a) or (b) from a photo but in this instance, white opals with only a gentle display of colour are not expensive and therefore it's likely this is real. The opals could be doublets or triplets though and so might be worth asking the seller whether he/she knows.
I think it would cost more to invest into imitating white opals. The brooch is pretty, though, and will be seen if you plan to wear it, especially on black/darker material. If the price is right, I'd buy it.
There is a strong possibility of the opals being real because they do not show a lot of colour play. It still could be a doublet or triplet and just because they are set with diamonds do not necessarily mean that they are real. Many stones in the Art Deco era were synthetics that are set with real diamonds.
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